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Etiology, Prognosis, and Hemostatic Function after Cerebral Infarction in Young Adults Stroke 20:477-482, Chancellor,A.M.,et al, 1989 See this aricle in Pubmed Article Abstract We retrospectively evaluated 66 patients younger than 40 years of age who presented with acute nonhemorrhagic cerebral infarction(n=63)or transient ischemic attacks(n=3)to determine the possible etiology and long-term outcome at a mean follow-up interval of 3 years after initial presentation.A probable cause for the stroke was identified in 24 patients (36%);this group included one women with a history of recurrent spontaneous abortions and a positive test for the presence of lupus anticoagulant.We performed detailed hemostatic investigations at follow-up in 38(90%)of the remaining 42 patients in whom the cause of the stroke was unknown or uncertain;results of the basic hemostatic screening tests (including that for fibrinogen)were uniformly normal.All 38 patients demonstrated a normal fibrinolytic response as measured by tissue plasminogen activator release to a standard venous occlusion stress test; concentration of the inhibitor of tissue plasminogen activator was not increased.No abnormalities in the concentrations of the inhibitory proteins C or S or antithrombin III were identified,and none of the 38 patients had evidence of a lupus anticoagulant.Neurologic recovery was complete or the residual disability mild in 46 of 59(78%)patients.Overall prognosis was excellent and independent of whether a precipitating factor for the stroke could be identified.

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(click to filter results - removes previous filter) cerebral infarction cerebrovascular accident cerebrovascular accident,etiology cerebrovascular accident,prognosis in cerebrovascular accident,young adult coagulopathy lupus anticoagulant prognosis

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